The tricky attacker has attracted the interest of the Giallorossi, but a transfer is still far away as talks between both clubs have yet to take place.
Head coach Zdenek Zeman is eager to add a winger to his squad in January, and the 65-year-old sees the Portugal international as the perfect addition to his roster.
Despite having amassed over 200 appearances for the Red Devils since joining in July 2007, Nani has struggled to earn a regular spot in Sir Alex Ferguson's starting XI this season, and could therefore be tempted to move on.
Roma are looking to sign the 26-year-old on a six-month loan deal with an option to make the move permanent at the end of the season, and the Giallorossi have already contacted the player's brother to determine whether Nani would be open to a move to the Stadio Olimpico side.
Nevertheless, a transfer could be a complicated matter as United are keen on receiving a figure in line with the €25.5m they originally shelled out for the player five years ago.
Additionally, Nani's wage demands could prove to be an obstacle as the attacker has no intention of accepting a pay-cut, and could opt to stay at United until his current deal expires in 2014 unless Roma match his current salary.
The former Sporting CP star had previously caught the attention of AC Milan and Juventus, but the Serie A giants' interest has since cooled down.